The group at St. Jude Children's Research Hospital will develop a methodology to integrate various types of genomic data (SNP genotypes, CNVs, mRNA expressions, etc.) and multiple related phenotypes into coherent genomic association networks (CGANs) that reveal inter-relationships among different types of genomic features and their associations with (effects on) phenotypes of interest in pharmacogenomics studies. The molecular mechanism underlying inter-related, multiple phenotypes can be a combination of effects from different genomic components at different levels. Thus integrated analyses combining various genomic features can help elucidate further the underlying biology than single-feature screening methods.
A network resource for coordination of statistical analysis and methods development in the PGRN.